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mertk inhibition  (TargetMol)


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    TargetMol mertk inhibition
    ( A ) ELISA analysis of serum IL-6 level ( n = 3 per group). ( B ) ELISA analysis of serum TNF-α level ( n = 3 per group). ( C and D ) Representative flow cytometry analysis plots and the quantification of Ly6C hi or Ly6C lo hepatic macrophages 36 hours after PHx ( n = 3 per group). ( E ) mRNA expression of Ly6C hi or Ly6C lo macrophage markers in isolated hepatic macrophages ( n = 3 per group). iNOS, inducible nitric oxide synthase; Arg-1, arginase-1. ( F ) RNA sequencing (RNA-seq) analysis of isolated hepatic macrophages 36 hours after PHx. Heatmap showed the proinflammatory (M1), reparative (M2), and efferocytosis gene expression profiles in Nlrp3 Δ mye mice and Nlrp3 fl/fl mice. ( G ) Bubble chart showing the top 20 of Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment of the significant up-regulated genes in Nlrp3 Δ mye mice. PPAR, peroxisome proliferator–activated receptor. ( H and I ) mRNA expression of efferocytosis genes in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( J ) Representative fluorescent images and quantification of engulfing ACs (TUNEL) by hepatic macrophages (CD68) in situ from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice 36 hours after PHx (scale bar, 50 μm) ( n = 5 per group). ( K ) Flow cytometry analysis of <t>MerTK</t> expression in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( L ) Representative fluorescent images and quantification of engulfing ACs (pHrodo labeled, green) by BMDMs (F-actin labeled, red) isolated from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice (scale bar, 50 μm) ( n = 5 per group). ( M ) mRNA expression of MerTK and HGF in isolated hepatic macrophages after cocultured with ACs ( n = 3 per group). Data are shown as means ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001. h, hours.
    Mertk Inhibition, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mertk inhibition/product/TargetMol
    Average 93 stars, based on 2 article reviews
    mertk inhibition - by Bioz Stars, 2026-04
    93/100 stars

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    1) Product Images from "NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis"

    Article Title: NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis

    Journal: Science Advances

    doi: 10.1126/sciadv.adq5786

    ( A ) ELISA analysis of serum IL-6 level ( n = 3 per group). ( B ) ELISA analysis of serum TNF-α level ( n = 3 per group). ( C and D ) Representative flow cytometry analysis plots and the quantification of Ly6C hi or Ly6C lo hepatic macrophages 36 hours after PHx ( n = 3 per group). ( E ) mRNA expression of Ly6C hi or Ly6C lo macrophage markers in isolated hepatic macrophages ( n = 3 per group). iNOS, inducible nitric oxide synthase; Arg-1, arginase-1. ( F ) RNA sequencing (RNA-seq) analysis of isolated hepatic macrophages 36 hours after PHx. Heatmap showed the proinflammatory (M1), reparative (M2), and efferocytosis gene expression profiles in Nlrp3 Δ mye mice and Nlrp3 fl/fl mice. ( G ) Bubble chart showing the top 20 of Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment of the significant up-regulated genes in Nlrp3 Δ mye mice. PPAR, peroxisome proliferator–activated receptor. ( H and I ) mRNA expression of efferocytosis genes in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( J ) Representative fluorescent images and quantification of engulfing ACs (TUNEL) by hepatic macrophages (CD68) in situ from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice 36 hours after PHx (scale bar, 50 μm) ( n = 5 per group). ( K ) Flow cytometry analysis of MerTK expression in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( L ) Representative fluorescent images and quantification of engulfing ACs (pHrodo labeled, green) by BMDMs (F-actin labeled, red) isolated from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice (scale bar, 50 μm) ( n = 5 per group). ( M ) mRNA expression of MerTK and HGF in isolated hepatic macrophages after cocultured with ACs ( n = 3 per group). Data are shown as means ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001. h, hours.
    Figure Legend Snippet: ( A ) ELISA analysis of serum IL-6 level ( n = 3 per group). ( B ) ELISA analysis of serum TNF-α level ( n = 3 per group). ( C and D ) Representative flow cytometry analysis plots and the quantification of Ly6C hi or Ly6C lo hepatic macrophages 36 hours after PHx ( n = 3 per group). ( E ) mRNA expression of Ly6C hi or Ly6C lo macrophage markers in isolated hepatic macrophages ( n = 3 per group). iNOS, inducible nitric oxide synthase; Arg-1, arginase-1. ( F ) RNA sequencing (RNA-seq) analysis of isolated hepatic macrophages 36 hours after PHx. Heatmap showed the proinflammatory (M1), reparative (M2), and efferocytosis gene expression profiles in Nlrp3 Δ mye mice and Nlrp3 fl/fl mice. ( G ) Bubble chart showing the top 20 of Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment of the significant up-regulated genes in Nlrp3 Δ mye mice. PPAR, peroxisome proliferator–activated receptor. ( H and I ) mRNA expression of efferocytosis genes in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( J ) Representative fluorescent images and quantification of engulfing ACs (TUNEL) by hepatic macrophages (CD68) in situ from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice 36 hours after PHx (scale bar, 50 μm) ( n = 5 per group). ( K ) Flow cytometry analysis of MerTK expression in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( L ) Representative fluorescent images and quantification of engulfing ACs (pHrodo labeled, green) by BMDMs (F-actin labeled, red) isolated from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice (scale bar, 50 μm) ( n = 5 per group). ( M ) mRNA expression of MerTK and HGF in isolated hepatic macrophages after cocultured with ACs ( n = 3 per group). Data are shown as means ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001. h, hours.

    Techniques Used: Enzyme-linked Immunosorbent Assay, Flow Cytometry, Expressing, Isolation, RNA Sequencing Assay, TUNEL Assay, In Situ, Labeling

    The NLRP3 inflammasome exhibited robust activation in macrophages during the initial phase of liver regeneration following 70% PHx. Blocking macrophage NLRP3 significantly enhanced liver regeneration, whereas overexpression of NLRP3 impaired it after PHx. Deficiency in Nlrp3 promoted MerTK-mediated efferocytosis, thereby inducing a pro-reparative Ly6C lo phenotype in macrophages. This image was drawn by the authors.
    Figure Legend Snippet: The NLRP3 inflammasome exhibited robust activation in macrophages during the initial phase of liver regeneration following 70% PHx. Blocking macrophage NLRP3 significantly enhanced liver regeneration, whereas overexpression of NLRP3 impaired it after PHx. Deficiency in Nlrp3 promoted MerTK-mediated efferocytosis, thereby inducing a pro-reparative Ly6C lo phenotype in macrophages. This image was drawn by the authors.

    Techniques Used: Activation Assay, Blocking Assay, Over Expression



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    mertk inhibition  (TargetMol)
    93
    TargetMol mertk inhibition
    ( A ) ELISA analysis of serum IL-6 level ( n = 3 per group). ( B ) ELISA analysis of serum TNF-α level ( n = 3 per group). ( C and D ) Representative flow cytometry analysis plots and the quantification of Ly6C hi or Ly6C lo hepatic macrophages 36 hours after PHx ( n = 3 per group). ( E ) mRNA expression of Ly6C hi or Ly6C lo macrophage markers in isolated hepatic macrophages ( n = 3 per group). iNOS, inducible nitric oxide synthase; Arg-1, arginase-1. ( F ) RNA sequencing (RNA-seq) analysis of isolated hepatic macrophages 36 hours after PHx. Heatmap showed the proinflammatory (M1), reparative (M2), and efferocytosis gene expression profiles in Nlrp3 Δ mye mice and Nlrp3 fl/fl mice. ( G ) Bubble chart showing the top 20 of Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment of the significant up-regulated genes in Nlrp3 Δ mye mice. PPAR, peroxisome proliferator–activated receptor. ( H and I ) mRNA expression of efferocytosis genes in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( J ) Representative fluorescent images and quantification of engulfing ACs (TUNEL) by hepatic macrophages (CD68) in situ from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice 36 hours after PHx (scale bar, 50 μm) ( n = 5 per group). ( K ) Flow cytometry analysis of <t>MerTK</t> expression in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( L ) Representative fluorescent images and quantification of engulfing ACs (pHrodo labeled, green) by BMDMs (F-actin labeled, red) isolated from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice (scale bar, 50 μm) ( n = 5 per group). ( M ) mRNA expression of MerTK and HGF in isolated hepatic macrophages after cocultured with ACs ( n = 3 per group). Data are shown as means ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001. h, hours.
    Mertk Inhibition, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mertk inhibition/product/TargetMol
    Average 93 stars, based on 1 article reviews
    mertk inhibition - by Bioz Stars, 2026-04
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    ( A ) ELISA analysis of serum IL-6 level ( n = 3 per group). ( B ) ELISA analysis of serum TNF-α level ( n = 3 per group). ( C and D ) Representative flow cytometry analysis plots and the quantification of Ly6C hi or Ly6C lo hepatic macrophages 36 hours after PHx ( n = 3 per group). ( E ) mRNA expression of Ly6C hi or Ly6C lo macrophage markers in isolated hepatic macrophages ( n = 3 per group). iNOS, inducible nitric oxide synthase; Arg-1, arginase-1. ( F ) RNA sequencing (RNA-seq) analysis of isolated hepatic macrophages 36 hours after PHx. Heatmap showed the proinflammatory (M1), reparative (M2), and efferocytosis gene expression profiles in Nlrp3 Δ mye mice and Nlrp3 fl/fl mice. ( G ) Bubble chart showing the top 20 of Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment of the significant up-regulated genes in Nlrp3 Δ mye mice. PPAR, peroxisome proliferator–activated receptor. ( H and I ) mRNA expression of efferocytosis genes in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( J ) Representative fluorescent images and quantification of engulfing ACs (TUNEL) by hepatic macrophages (CD68) in situ from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice 36 hours after PHx (scale bar, 50 μm) ( n = 5 per group). ( K ) Flow cytometry analysis of MerTK expression in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( L ) Representative fluorescent images and quantification of engulfing ACs (pHrodo labeled, green) by BMDMs (F-actin labeled, red) isolated from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice (scale bar, 50 μm) ( n = 5 per group). ( M ) mRNA expression of MerTK and HGF in isolated hepatic macrophages after cocultured with ACs ( n = 3 per group). Data are shown as means ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001. h, hours.

    Journal: Science Advances

    Article Title: NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis

    doi: 10.1126/sciadv.adq5786

    Figure Lengend Snippet: ( A ) ELISA analysis of serum IL-6 level ( n = 3 per group). ( B ) ELISA analysis of serum TNF-α level ( n = 3 per group). ( C and D ) Representative flow cytometry analysis plots and the quantification of Ly6C hi or Ly6C lo hepatic macrophages 36 hours after PHx ( n = 3 per group). ( E ) mRNA expression of Ly6C hi or Ly6C lo macrophage markers in isolated hepatic macrophages ( n = 3 per group). iNOS, inducible nitric oxide synthase; Arg-1, arginase-1. ( F ) RNA sequencing (RNA-seq) analysis of isolated hepatic macrophages 36 hours after PHx. Heatmap showed the proinflammatory (M1), reparative (M2), and efferocytosis gene expression profiles in Nlrp3 Δ mye mice and Nlrp3 fl/fl mice. ( G ) Bubble chart showing the top 20 of Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment of the significant up-regulated genes in Nlrp3 Δ mye mice. PPAR, peroxisome proliferator–activated receptor. ( H and I ) mRNA expression of efferocytosis genes in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( J ) Representative fluorescent images and quantification of engulfing ACs (TUNEL) by hepatic macrophages (CD68) in situ from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice 36 hours after PHx (scale bar, 50 μm) ( n = 5 per group). ( K ) Flow cytometry analysis of MerTK expression in isolated hepatic macrophages 36 hours after PHx ( n = 3 per group). ( L ) Representative fluorescent images and quantification of engulfing ACs (pHrodo labeled, green) by BMDMs (F-actin labeled, red) isolated from Nlrp3 Δ mye mice and Nlrp3 fl/fl mice (scale bar, 50 μm) ( n = 5 per group). ( M ) mRNA expression of MerTK and HGF in isolated hepatic macrophages after cocultured with ACs ( n = 3 per group). Data are shown as means ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001. h, hours.

    Article Snippet: For MerTK inhibition, UNC2025 (TargetMol, no. T7007) was administrated intraperitoneally to a concentration of 50 mg/kg 2 hours before and 24 hours after PHx.

    Techniques: Enzyme-linked Immunosorbent Assay, Flow Cytometry, Expressing, Isolation, RNA Sequencing Assay, TUNEL Assay, In Situ, Labeling

    The NLRP3 inflammasome exhibited robust activation in macrophages during the initial phase of liver regeneration following 70% PHx. Blocking macrophage NLRP3 significantly enhanced liver regeneration, whereas overexpression of NLRP3 impaired it after PHx. Deficiency in Nlrp3 promoted MerTK-mediated efferocytosis, thereby inducing a pro-reparative Ly6C lo phenotype in macrophages. This image was drawn by the authors.

    Journal: Science Advances

    Article Title: NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis

    doi: 10.1126/sciadv.adq5786

    Figure Lengend Snippet: The NLRP3 inflammasome exhibited robust activation in macrophages during the initial phase of liver regeneration following 70% PHx. Blocking macrophage NLRP3 significantly enhanced liver regeneration, whereas overexpression of NLRP3 impaired it after PHx. Deficiency in Nlrp3 promoted MerTK-mediated efferocytosis, thereby inducing a pro-reparative Ly6C lo phenotype in macrophages. This image was drawn by the authors.

    Article Snippet: For MerTK inhibition, UNC2025 (TargetMol, no. T7007) was administrated intraperitoneally to a concentration of 50 mg/kg 2 hours before and 24 hours after PHx.

    Techniques: Activation Assay, Blocking Assay, Over Expression